Literature DB >> 11029491

Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.

H Shirato1, H Shima, H Nakagama, H Fukuda, Y Watanabe, K Ogawa, Y Matsuda, K Kikuchi.   

Abstract

The serine/threonine protein phosphatase type 5 (PP5) gene expression was ubiquitously observed among all the tissues examined, but being at the lowest level in the liver. The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver. The PP5 gene was mapped to rat chromosome 1q22.1. This region has been identified to have linkage homology among human, mouse and rat, and is known to be associated with several tumor types. Taken together, the present results strongly suggest important roles of PP5 in tumorigenesis.

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Year:  2000        PMID： 11029491     DOI： 10.3892/ijo.17.5.909

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  8 in total

1.  Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).

Authors:  Lauren Amable; Nina Grankvist; Jason W Largen; Henrik Ortsäter; Åke Sjöholm; Richard E Honkanen
Journal:  J Biol Chem       Date:  2011-09-15       Impact factor: 5.157

2.  Knockdown of serine/threonine protein phosphatase 5 enhances gemcitabine sensitivity by promoting apoptosis in pancreatic cancer cells in vitro.

Authors:  Jinhui Zhu; Yun Ji; Yuanquan Yu; Yun Jin; Xiaoxiao Zhang; Jiale Zhou; Yan Chen
Journal:  Oncol Lett       Date:  2018-03-28       Impact factor: 2.967

3.  Serine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma.

Authors:  Xinglong Zhi; Hongqi Zhang; Chuan He; Yukui Wei; Lisong Bian; Guilin Li
Journal:  Cell Mol Neurobiol       Date:  2015-03-22       Impact factor: 5.046

4.  Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.

Authors:  Teresa Golden; Ileana V Aragon; Beth Rutland; J Allan Tucker; Lalita A Shevde; Rajeev S Samant; Guofei Zhou; Lauren Amable; Danalea Skarra; Richard E Honkanen
Journal:  Biochim Biophys Acta       Date:  2008-01-26

Review 5.  The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer.

Authors:  Teresa Golden; Mark Swingle; Richard E Honkanen
Journal:  Cancer Metastasis Rev       Date:  2008-06       Impact factor: 9.264

6.  Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.

Authors:  Ming Chen; Jian-Min Lv; Jian-Qing Ye; Xin-Gang Cui; Fa-Jun Qu; Lu Chen; Xi Liu; Xiu-Wu Pan; Lin Li; Hai Huang; Qi-Wei Yang; Jie Chen; Lin-Hui Wang; Yi Gao; Dan-Feng Xu
Journal:  Int J Oncol       Date:  2017-05-16       Impact factor: 5.650

Review 7.  Deciphering the Roles of Thiazolidinediones and PPARγ in Bladder Cancer.

Authors:  Melody Chiu; Lucien McBeth; Puneet Sindhwani; Terry D Hinds
Journal:  PPAR Res       Date:  2017-02-28       Impact factor: 4.964

8.  PPP5C promotes cell proliferation and survival in human prostate cancer by regulating of the JNK and ERK1/2 phosphorylation.

Authors:  Jian-Min Lv; Lu Chen; Yi Gao; Hai Huang; Xiu-Wu Pan; Xi Liu; Ming Chen; Fa-Jun Qu; Lin Li; Jun-Kai Wang; Xin-Gang Cui; Dan-Feng Xu
Journal:  Onco Targets Ther       Date:  2018-09-12       Impact factor: 4.147
  8 in total

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