Literature DB >> 11029195

Synthesis of a primary metabolite of cannabidiol.

S Tchilibon1, R Mechoulam.   

Abstract

Cannabidiol 1 is the major nonpsychotropic, neutral constituent in most cannabis preparations. It is devoid of the psychoactive properties typical of cannabis; however, it produces numerous, potentially therapeutic pharmacological effects, some of which may be due to its metabolites. We report now the first total synthesis of 7-hydroxycannabidiol 2, a primary metabolite of cannabidiol, in an eight-step procedure.

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Year:  2000        PMID： 11029195     DOI： 10.1021/ol006369a

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.

Authors:  T Bisogno; L Hanus; L De Petrocellis; S Tchilibon; D E Ponde; I Brandi; A S Moriello; J B Davis; R Mechoulam; V Di Marzo
Journal:  Br J Pharmacol       Date:  2001-10       Impact factor: 8.739

2.  Synthesis of (+)-didemniserinolipid B: application of a 2-allyl-4-fluorophenyl auxiliary for relay ring-closing metathesis.

Authors:  Christopher C Marvin; Eric A Voight; Judy M Suh; Christopher L Paradise; Steven D Burke
Journal:  J Org Chem       Date:  2008-09-24       Impact factor: 4.354

Review 3.  An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

Authors:  Paula Morales; Patricia H Reggio; Nadine Jagerovic
Journal:  Front Pharmacol       Date:  2017-06-28       Impact factor: 5.810

4.  The antimicrobial potential of cannabidiol.

Authors:  Mark A T Blaskovich; Angela M Kavanagh; Alysha G Elliott; Bing Zhang; Soumya Ramu; Maite Amado; Gabrielle J Lowe; Alexandra O Hinton; Do Minh Thu Pham; Johannes Zuegg; Neil Beare; Diana Quach; Marc D Sharp; Joe Pogliano; Ashleigh P Rogers; Dena Lyras; Lendl Tan; Nicholas P West; David W Crawford; Marnie L Peterson; Matthew Callahan; Michael Thurn
Journal:  Commun Biol       Date:  2021-01-19

Review 5.  Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research.

Authors:  Diego Caprioglio; Hawraz Ibrahim M Amin; Orazio Taglialatela-Scafati; Eduardo Muñoz; Giovanni Appendino
Journal:  Biomolecules       Date:  2022-08-06

Review 6.  Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy.

Authors:  István Ujváry; Lumír Hanuš
Journal:  Cannabis Cannabinoid Res       Date:  2016-03-01
  6 in total

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