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Literature DB >> 11029074

What is characteristic of fungal lysine synthesis through the alpha-aminoadipate pathway?

Abstract

Recent finding that a prokaryote synthesizes lysine through the alpha-aminoadipate pathway demonstrates that the lysine synthesis through the alpha-aminoadipate pathway is not typical of fungi. However, the fungal lysine biosynthesis is not completely the same as the prokaryotic one. We point out that alpha-aminoadipate reductase is a key enzyme to the evolution of fungal lysine synthesis. In addition, fungi have two different saccharopine dehydrogenases, which is also characteristic of fungi.

Entities: Chemical

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Year: 2000 PMID： 11029074 DOI： 10.1007/s002390010091

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

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Cited

12 in total

1. Functional analysis through site-directed mutations and phylogeny of the Candida albicans LYS1-encoded saccharopine dehydrogenase.

Authors: Shujuan Guo; Richard C Garrad; J K Bhattacharjee
Journal: Mol Genet Genomics Date: 2005-11-15 Impact factor: 3.291

2. Different elongation pathways in the biosynthesis of acyl groups of trichome exudate sugar esters from various solanaceous plants.

Authors: Antoaneta B Kroumova; George J Wagner
Journal: Planta Date: 2003-01-18 Impact factor: 4.116

3. Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.

Authors: E M Martín de Valmaseda; S Campoy; L Naranjo; J Casqueiro; J F Martín
Journal: Mol Genet Genomics Date: 2005-10-20 Impact factor: 3.291

4. A lysine accumulation phenotype of ScIpk2Delta mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase.

Authors: Samuel E K Caddick; Christopher J Harrison; Ioanna Stavridou; Sue Johnson; Charles A Brearley
Journal: Biochem J Date: 2007-05-01 Impact factor: 3.857

5. Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.

Authors: Andrei S Halavaty; Youngchang Kim; George Minasov; Ludmilla Shuvalova; Ievgeniia Dubrovska; James Winsor; Min Zhou; Olena Onopriyenko; Tatiana Skarina; Leka Papazisi; Keehwan Kwon; Scott N Peterson; Andrzej Joachimiak; Alexei Savchenko; Wayne F Anderson
Journal: Acta Crystallogr D Biol Crystallogr Date: 2012-09-13

What is characteristic of fungal lysine synthesis through the alpha-aminoadipate pathway?

1. Functional analysis through site-directed mutations and phylogeny of the Candida albicans LYS1-encoded saccharopine dehydrogenase.

2. Different elongation pathways in the biosynthesis of acyl groups of trichome exudate sugar esters from various solanaceous plants.

3. Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.

4. A lysine accumulation phenotype of ScIpk2Delta mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase.

5. Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.

6. Comparative analyses of homocitrate synthase genes of ascomycetous yeasts.

7. Aminoadipate reductase gene: a new fungal-specific gene for comparative evolutionary analyses.

Review 8. Regulation and compartmentalization of β-lactam biosynthesis.

9. Mechanism and substrate recognition of human holo ACP synthase.

10. Molecular evolution of adenylating domain of aminoadipate reductase.