Associations of apolipoprotein E concentration and polymorphism with lipids and apolipoprotein levels in Chinese from Beijing and Shanghai.

The association of apolipoprotein E concentration and common polymorphism (codons 112/158) with lipid and apolipoprotein concentrations was studied in two Chinese healthy population samples from Beijing (n=99) and Shanghai (n=67). Body mass index and apolipoproteins E and AI and triglyceride concentrations were significantly different between the two populations (0.001<p<0.05), but apolipoprotein E common allele frequencies were not significantly different. Apolipoprotein E concentration was independently associated with apolipoproteins B and AI, total cholesterol and triglyceride concentrations in the Beijing group, but only with total cholesterol and apolipoprotein AI concentrations in the Shanghai group. Apolipoprotein E polymorphism was significantly associated with apolipoproteins E and AI, and triglyceride concentrations in the Beijing subjects (0.001<p<0.01), whereas apolipoprotein E polymorphism was significantly related only to apolipoprotein E concentration in the Shanghai group (p<0.001). This preliminary study with a limited number of subjects shows that the relations between both apolipoprotein E genotypes and concentration with lipid traits are not the same in the two studied Chinese populations.