OBJECTIVES: To investigate whether the relationship between demographic and disease-related variables and disability is constant during the first five years of inflammatory polyarthritis (IP) and to identify the contribution from involvement of specific joint areas to overall disability. METHODS: 684 patients referred to the Norfolk Arthritis Register were followed for five years using the Health Assessment Questionnaire (HAQ). The relationship between disability and demographic and clinical variables was analyzed using a multi-level modelling approach. RESULTS: Female gender, older age at symptom onset (> or = 64 years), joint involvement at six specific sites, joint tenderness and the number of deformed joints were all independently associated with disability (HAQ > or = 1.00). Similar results were obtained using a more stringent cut-off (HAQ > or = 1.50) or when analysis was restricted to the 325 patients who satisfied the 1987 ARA list criteria for rheumatoid arthritis. CONCLUSION: Disability, as measured by the HAQ, was associated with a large number of independent factors over the first five years of disease.
OBJECTIVES: To investigate whether the relationship between demographic and disease-related variables and disability is constant during the first five years of inflammatory polyarthritis (IP) and to identify the contribution from involvement of specific joint areas to overall disability. METHODS: 684 patients referred to the Norfolk Arthritis Register were followed for five years using the Health Assessment Questionnaire (HAQ). The relationship between disability and demographic and clinical variables was analyzed using a multi-level modelling approach. RESULTS: Female gender, older age at symptom onset (> or = 64 years), joint involvement at six specific sites, joint tenderness and the number of deformed joints were all independently associated with disability (HAQ > or = 1.00). Similar results were obtained using a more stringent cut-off (HAQ > or = 1.50) or when analysis was restricted to the 325 patients who satisfied the 1987 ARA list criteria for rheumatoid arthritis. CONCLUSION: Disability, as measured by the HAQ, was associated with a large number of independent factors over the first five years of disease.
Authors: N J Wiles; D G Scott; E M Barrett; P Merry; E Arie; K Gaffney; A J Silman; D P Symmons Journal: Ann Rheum Dis Date: 2001-10 Impact factor: 19.103
Authors: Carlo A Scirè; Suzanne M M Verstappen; Hoda Mirjafari; Diane K Bunn; Mark Lunt; Carlomaurizio Montecucco; Ian N Bruce; Deborah P M Symmons Journal: Arthritis Care Res (Hoboken) Date: 2011-07 Impact factor: 4.794
Authors: Natacha Courvoisier; Maxime Dougados; Alain Cantagrel; Philippe Goupille; Olivier Meyer; Jean Sibilia; Jean Pierre Daures; Bernard Combe Journal: Arthritis Res Ther Date: 2008-09-04 Impact factor: 5.156
Authors: Ying-Ying Leung; Kwok-Wah Ho; Edmund K Li; Martin Li; Lai-Wa Kwok; Priscilla C Wong; Tena K Li; Tracy Y Zhu; Emily W Kun; Lai-Shan Tam Journal: BMC Musculoskelet Disord Date: 2014-08-26 Impact factor: 2.362