| Literature DB >> 11027839 |
M L Jongsma1, C M van Rijn, J van Egmond, W J van Schaijk, A Sambeth, A M Coenen.
Abstract
Though being a sedative, diazepam increases beta-activity in the electroencephalogram (EEG). Diazepam also affects auditory evoked potentials (AEPs). We investigated if the effect of diazepam on AEPs could be ascribed to its beta-increasing effect. Eight rats received vehicle and diazepam counterbalanced. AEPs were ranked in ten categories according to the percentages of beta-activity in the pre-stimulus electroencephalogram (EEG). With vehicle, the P(29), N(51) and P(67) AEP components increased and cross-correlation coefficients (CCCs) declined with increasing beta-activity. With diazepam AEP components and CCCs remained unchanged. All AEPs with diazepam closely resembled the AEP of the lowest beta-category obtained with vehicle. We conclude that the effect of diazepam on AEPs can not be ascribed to its beta-enhancing effect. Diazepam disrupts the normal AEP-EEG relation such that diazepam-effects on AEPs seem to reflect the sedative effects of diazepam and not its beta-increasing effects.Entities:
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Year: 2000 PMID： 11027839 DOI： 10.1016/s0304-3940(00)01496-8
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046