Literature DB >> 11023789

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP.

R N De Guzman1, H Y Liu, M Martinez-Yamout, H J Dyson, P E Wright.   

Abstract

The TAZ2 (CH3) domain of the transcriptional adapter protein CBP has been implicated in direct functional interactions with numerous cellular transcription factors and viral oncoproteins. The solution structure of the TAZ2 domain of murine CBP has been determined by nuclear magnetic resonance (NMR). The protein adopts a novel helical fold stabilized by three zinc ions, each of which is bound to one histidine and three cysteine ligands in HCCC-type motifs. Each zinc-binding site is formed from the carboxy terminus of an alpha-helix, a short loop, and the amino terminus of the next alpha-helix. A peptide derived from the N-terminal transactivation domain of p53 binds specifically to one face of the TAZ2 domain. The close similarities between the TAZ2 and TAZ1 (CH1 domain of CBP/p300) sequences suggest that both domains will adopt similar three-dimensional structures. Copyright 2000 Academic Press.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11023789     DOI： 10.1006/jmbi.2000.4141

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  51 in total

1.  Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domains.

Authors:  Chao Zhong Song; Kimberly Keller; Yangchao Chen; Ken Murata; George Stamatoyannopoulos
Journal:  Biochem Biophys Res Commun       Date:  2002-08-09       Impact factor: 3.575

2.  Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP.

Authors:  Munehito Arai; Josephine C Ferreon; Peter E Wright
Journal:  J Am Chem Soc       Date:  2012-02-15       Impact factor: 15.419

3.  Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha.

Authors:  Hyun-Seo Kang; Mary L Nelson; Cameron D Mackereth; Manuela Schärpf; Barbara J Graves; Lawrence P McIntosh
Journal:  J Mol Biol       Date:  2008-01-30       Impact factor: 5.469

4.  Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.

Authors:  Sarah Burge; Daniel P Teufel; Fiona M Townsley; Stefan M V Freund; Mark Bycroft; Alan R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-13       Impact factor: 11.205

5.  Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2.

Authors:  Josephine C Ferreon; Chul Won Lee; Munehito Arai; Maria A Martinez-Yamout; H Jane Dyson; Peter E Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-08       Impact factor: 11.205

6.  Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

Authors:  Mark Wells; Henning Tidow; Trevor J Rutherford; Phineus Markwick; Malene Ringkjobing Jensen; Efstratios Mylonas; Dmitri I Svergun; Martin Blackledge; Alan R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-07       Impact factor: 11.205

7.  Structure of the Taz2 domain of p300: insights into ligand binding.

Authors:  Maria Miller; Zbigniew Dauter; Scott Cherry; Joseph E Tropea; Alexander Wlodawer
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-11-17

8.  The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.

Authors:  Erin A Kimbrel; Andrew L Kung
Journal:  J Biol Chem       Date:  2009-03-17       Impact factor: 5.157

9.  Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1.

Authors:  Yong Li; Tomoki Kimura; Ryan W Huyck; John H Laity; Glen K Andrews
Journal:  Mol Cell Biol       Date:  2008-05-05       Impact factor: 4.272

10.  Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A.

Authors:  Marina R Lochhead; Alexandra D Brown; Alyssa C Kirlin; Seth Chitayat; Kim Munro; Jane E Findlay; George S Baillie; David P LeBrun; David N Langelaan; Steven P Smith
Journal:  J Biol Chem       Date:  2020-02-25       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.