| Literature DB >> 11021642 |
E K Seo1, M C Wani, M E Wall, H Navarro, R Mukherjee, N R Farnsworth, A D Kinghorn.
Abstract
Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic.Entities:
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Year: 2000 PMID: 11021642 DOI: 10.1016/s0031-9422(00)00208-9
Source DB: PubMed Journal: Phytochemistry ISSN: 0031-9422 Impact factor: 4.072