PURPOSE: To elucidate the origin of the abnormal fundus reflex in Oguchi disease. METHODS: The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and an infrared laser (780 nm). RESULTS: Diffuse, fine, white particles, which do not exist in normal subjects, were clearly demonstrated only with the helium-neon laser. After 4-hour dark adaptation, the abnormal particles disappeared, but then they reappeared gradually during 30 minutes of light adaptation, in accordance with the golden metallic reflex. CONCLUSION: The white particles found by helium-neon laser could be the origin of the abnormal fundus reflex in Oguchi disease.
PURPOSE: To elucidate the origin of the abnormal fundus reflex in Oguchi disease. METHODS: The ocular fundus of a 63-year-old woman who showed a homozygous arrestin 1147delA mutation was observed by scanning laser ophthalmoscopy with the use of an argon blue laser (wavelength, 488 nm), a helium-neon laser (633 nm), and an infrared laser (780 nm). RESULTS: Diffuse, fine, white particles, which do not exist in normal subjects, were clearly demonstrated only with the helium-neon laser. After 4-hour dark adaptation, the abnormal particles disappeared, but then they reappeared gradually during 30 minutes of light adaptation, in accordance with the golden metallic reflex. CONCLUSION: The white particles found by helium-neon laser could be the origin of the abnormal fundus reflex in Oguchi disease.
Authors: Maleeha Azam; Rob W J Collin; Muhammad Imran Khan; Syed Tahir Abbas Shah; Nadeem Qureshi; Muhammad Ajmal; Anneke I den Hollander; Raheel Qamar; Frans P M Cremers Journal: Mol Vis Date: 2009-09-05 Impact factor: 2.367
Authors: Pooja Godara; Robert F Cooper; Panagiotis I Sergouniotis; Melissa A Diederichs; Megan R Streb; Mohamed A Genead; J Jason McAnany; Andrew R Webster; Anthony T Moore; Adam M Dubis; Maureen Neitz; Alfredo Dubra; Edwin M Stone; Gerald A Fishman; Dennis P Han; Michel Michaelides; Joseph Carroll Journal: Am J Ophthalmol Date: 2012-09-07 Impact factor: 5.258
Authors: Nadia K Waheed; Ahmed H Qavi; Sarah N Malik; Maleeha Maria; Moeen Riaz; Frans P M Cremers; Maleeha Azam; Raheel Qamar Journal: Mol Vis Date: 2012-05-12 Impact factor: 2.367