Literature DB >> 11020263

Simple 1,2-aminoalcohols as strain-specific antimalarial agents.

J Howarth1, D G Lloyd.   

Abstract

We report here the in vitro activity of a selection of 1, 2-aminoalcohol-containing compounds against cloned strains of human Plasmodium falciparum. These compounds exhibit moderate antimalarial activity but a high degree of strain specificity, preferentially inhibiting a chloroquine-resistant strain of the organism.

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Year:  2000        PMID： 11020263     DOI： 10.1093/jac/46.4.625

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  2 in total

1.  The thermophilic, homohexameric aminopeptidase of Borrelia burgdorferi is a member of the M29 family of metallopeptidases.

Authors:  Patrícia B Bertin; Silene P Lozzi; Jerrilyn K Howell; Glória Restrepo-Cadavid; David Neves; Antonio R L Teixeira; Marcelo V de Sousa; Steven J Norris; Jaime M Santana
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

2.  In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis.

Authors:  Ana L Legarda-Ceballos; Julio López-Abán; Esther Del Olmo; Ricardo Escarcena; Luis A Bustos; Jose Rojas-Caraballo; Belén Vicente; Pedro Fernández-Soto; Arturo San Feliciano; Antonio Muro
Journal:  Parasit Vectors       Date:  2016-06-28       Impact factor: 3.876
  2 in total

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