| Literature DB >> 11017149 |
Y Q Wei1, Q R Wang, X Zhao, L Yang, L Tian, Y Lu, B Kang, C J Lu, M J Huang, Y Y Lou, F Xiao, Q M He, J M Shu, X J Xie, Y Q Mao, S Lei, F Luo, L Q Zhou, C E Liu, H Zhou, Y Jiang, F Peng, L P Yuan, Q Li, Y Wu, J Y Liu.
Abstract
The breaking of immune tolerance against autologous angiogenic endothelial cells should be a useful approach for cancer therapy. Here we show that immunotherapy of tumors using fixed xenogeneic whole endothelial cells as a vaccine was effective in affording protection from tumor growth, inducing regression of established tumors and prolonging survival of tumor-bearing mice. Furthermore, autoreactive immunity targeting to microvessels in solid tumors was induced and was probably responsible for the anti-tumor activity. These observations may provide a new vaccine strategy for cancer therapy through the induction of an autoimmune response against the tumor endothelium in a cross-reaction.Entities:
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Year: 2000 PMID： 11017149 DOI： 10.1038/80506
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440