Literature DB >> 11015593

Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes.

J A Warrington1, A Nair, M Mahadevappa, M Tsyganskaya.   

Abstract

Gene expression levels of about 7,000 genes were measured in 11 different human adult and fetal tissues using high-density oligonucleotide arrays to identify genes involved in cellular maintenance. The tissues share a set of 535 transcripts that are turned on early in fetal development and stay on throughout adulthood. Because our goal was to identify genes that are involved in maintaining cellular function in normal individuals, we minimized the effect of individual variation by screening mRNA pooled from many individuals. This information is useful for establishing average expression levels in normal individuals. Additionally, we identified transcripts uniquely expressed in each of the 11 tissues.

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Year:  2000        PMID： 11015593     DOI： 10.1152/physiolgenomics.2000.2.3.143

Source DB:  PubMed          Journal:  Physiol Genomics        ISSN： 1094-8341            Impact factor:   3.107


  176 in total

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10.  The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function.

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Journal:  Nucleic Acids Res       Date:  2002-08-15       Impact factor: 16.971
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