Historical perspective of myocardial infarction.

The history of myocardial infarction ('coronary thrombosis'), a condition which was only recognised as a clinical entity in the 20th century, is reviewed up to the time of the introduction of the intensive coronary care units. Early observations of presentations, complications, diagnosis and treatment of the disease are emphasised. The increase in incidence of myocardial infarction, real or relative, is discussed and the remarkable variation shown in earlier reports on the mortality rate of myocardial infarction is explained. Many of the important principles which revolutionised the management of the disease through coronary care units, are evident in the earlier reports.