| Literature DB >> 11013688 |
T Z Aziz1, L Davies, J Stein, S France.
Abstract
Akinesia is the most disabling symptom of Parkinson's disease. The neural mechanisms underlying it probably involve the descending projections of the basal ganglia to the brain stem as it improves after a pallidotomy or subthalamic nucleotomy but not after a thalamotomy. We describe the effects of lesioning the pedunculopontine nucleus in the normal primate in generating an akinetic syndrome. The possible clinical implications of this study are discussed.Entities:
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Year: 1998 PMID： 11013688 DOI： 10.1080/02688699845078
Source DB: PubMed Journal: Br J Neurosurg ISSN： 0268-8697 Impact factor: 1.596