J P Rovers1, M L de Jode, M F Grahn. 1. Academic Department of Surgery, St. Bartholomew's and The Royal London Hospital School of Medicine & Dentistry, Whitechapel, London, United Kingdom.
Abstract
BACKGROUND AND OBJECTIVE: Penetration of tissues by activating light ultimately limits the size of the lesions achievable in interstitial photodynamic therapy. Measurements of the wavelength-dependence of tissue optical properties suggest that substantial improvements may be possible, particularly in pigmented organs such as the liver, by using drugs absorbing at near infrared wavelengths. STUDY DESIGN/ MATERIALS AND METHODS: In this study, the extent of light induced necrosis with the photosensitive agents Photofrin (activated at 632 nm), meta-tetra(hydroxyphenyl)chlorin (mTHPC) (activated at 652 nm) and 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (mTHPBC) (activated at 740 nm) are compared in normal rat liver. Interstitial irradiation of mTHPBC-sensitized liver tissue resulted in significantly larger necrotic areas than irradiation of Photofrin and mTHPC-sensitised livers. CONCLUSION: The results illustrate the advantage of near-infrared photosensitizer activation and point to a specific role for mTHPBC in the interstitial treatment of liver tumours. Copyright 2000 Wiley-Liss, Inc.
BACKGROUND AND OBJECTIVE: Penetration of tissues by activating light ultimately limits the size of the lesions achievable in interstitial photodynamic therapy. Measurements of the wavelength-dependence of tissue optical properties suggest that substantial improvements may be possible, particularly in pigmented organs such as the liver, by using drugs absorbing at near infrared wavelengths. STUDY DESIGN/ MATERIALS AND METHODS: In this study, the extent of light induced necrosis with the photosensitive agents Photofrin (activated at 632 nm), meta-tetra(hydroxyphenyl)chlorin (mTHPC) (activated at 652 nm) and 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (mTHPBC) (activated at 740 nm) are compared in normal rat liver. Interstitial irradiation of mTHPBC-sensitized liver tissue resulted in significantly larger necrotic areas than irradiation of Photofrin and mTHPC-sensitised livers. CONCLUSION: The results illustrate the advantage of near-infrared photosensitizer activation and point to a specific role for mTHPBC in the interstitial treatment of liver tumours. Copyright 2000 Wiley-Liss, Inc.
Authors: Liyi Huang; Ying-Ying Huang; Pawel Mroz; George P Tegos; Timur Zhiyentayev; Sulbha K Sharma; Zongshun Lu; Thiagarajan Balasubramanian; Michael Krayer; Christian Ruzié; Eunkyung Yang; Hooi Ling Kee; Christine Kirmaier; James R Diers; David F Bocian; Dewey Holten; Jonathan S Lindsey; Michael R Hamblin Journal: Antimicrob Agents Chemother Date: 2010-07-12 Impact factor: 5.191
Authors: Samana Shrestha; Jing Wu; Bindeshwar Sah; Adam Vanasse; Leon N Cooper; Lun Ma; Gen Li; Huibin Zheng; Wei Chen; Michael P Antosh Journal: Proc Natl Acad Sci U S A Date: 2019-08-01 Impact factor: 11.205
Authors: Thomas J Vogl; Katrin Eichler; Martin G Mack; Stephan Zangos; Christopher Herzog; Axel Thalhammer; Kerstin Engelmann Journal: Eur Radiol Date: 2004-03-26 Impact factor: 5.315