Literature DB >> 1101260

Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.

E M Wise, M M Abou-Donia.   

Abstract

Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide-resistant dihydropteroate synthase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase, EC 2.5.1.15) in addition to the normal sensitive enzyme. The resistant dihydropteroate synthases examined are determined by an R plasmid and are smaller and less heat stable than the normal sulfonamide-sensitive enzyme. One synthase resistant to any sulfonamide tested, and to sulfanilic and arsanilic acids, was still inhibited by several non-sulfonamide analogs of p-aminobenzoate. Citrobacter and Klebsiella pneumoniae strains also show similar mechanisms of sulfonamide resistance.

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Year:  1975        PMID： 1101260      PMCID： PMC432821          DOI： 10.1073/pnas.72.7.2621

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  THE ENZYMATIC SYNTHESIS OF FOLATE-LIKE COMPOUNDS FROM HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHATE.

Authors:  T SHIOTA; M N DISRAELY; M P MCCANN
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.

Authors:  B ROTH; E A FALCO; G H HITCHINGS; S R BUSHBY
Journal:  J Med Pharm Chem       Date:  1962-11

3.  Analysis of the Biochemical Mechanism of Drug Resistance in Certain Bacterial Mutants.

Authors:  B D Davis; W K Maas
Journal:  Proc Natl Acad Sci U S A       Date:  1952-09       Impact factor: 11.205

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  A new dihydrofolate reductase with low trimethoprim sensitivity induced by an R factor mediating high resistance to trimethoprim.

Authors:  O Sköld; A Widh
Journal:  J Biol Chem       Date:  1974-07-10       Impact factor: 5.157

Review 6.  Molecular structure of bacterial plasmids.

Authors:  R C Clowes
Journal:  Bacteriol Rev       Date:  1972-09

7.  Inhibitor binding analysis of dihydrofolate reductases from various species.

Authors:  J J Burchall; G H Hitchings
Journal:  Mol Pharmacol       Date:  1965-09       Impact factor: 4.436

8.  The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate.

Authors:  T Shiota; C M Baugh; R Jackson; R Dillard
Journal:  Biochemistry       Date:  1969-12       Impact factor: 3.162

9.  The enzymatic synthesis of dihydrofolate and dihydropteroate in cell-free preparations from wild-type and sulfonamide-resistant pneumococcus.

Authors:  P J Ortiz; R D Hotchkiss
Journal:  Biochemistry       Date:  1966-01       Impact factor: 3.162

10.  The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid.

Authors:  D P Richey; G M Brown
Journal:  J Biol Chem       Date:  1969-03-25       Impact factor: 5.157
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  24 in total

1.  Sulfonamide resistance gene for plant transformation.

Authors:  F Guerineau; L Brooks; J Meadows; A Lucy; C Robinson; P Mullineaux
Journal:  Plant Mol Biol       Date:  1990-07       Impact factor: 4.076

2.  Organization of two sulfonamide resistance genes on plasmids of gram-negative bacteria.

Authors:  G Swedberg
Journal:  Antimicrob Agents Chemother       Date:  1987-02       Impact factor: 5.191

3.  RSF1010 and a conjugative plasmid contain sulII, one of two known genes for plasmid-borne sulfonamide resistance dihydropteroate synthase.

Authors:  P Rådström; G Swedberg
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

Review 4.  [Membrane permeability and antibiotic resistance in bacteria].

Authors:  V Braun
Journal:  Naturwissenschaften       Date:  1977-03

Review 5.  Trimethoprim and sulfonamide resistance.

Authors:  P Huovinen; L Sundström; G Swedberg; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

6.  Bactericidal activity of trimethoprim alone and in combination with sulfamethoxazole on susceptible and resistant Escherichia coli K-12.

Authors:  S G Amyes
Journal:  Antimicrob Agents Chemother       Date:  1982-02       Impact factor: 5.191

7.  Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100.

Authors:  W S Dallas; J E Gowen; P H Ray; M J Cox; I K Dev
Journal:  J Bacteriol       Date:  1992-09       Impact factor: 3.490

8.  Transition of deletion mutants of the composite resistance plasmid NR1 in Escherichia coli and Salmonella typhimurium.

Authors:  G A Huffman; R H Rownd
Journal:  J Bacteriol       Date:  1984-08       Impact factor: 3.490

9.  Genetic analyses of sulfonamide resistance and its dissemination in gram-negative bacteria illustrate new aspects of R plasmid evolution.

Authors:  P Rådström; G Swedberg; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1991-09       Impact factor: 5.191

10.  Characterization of different plasmid-borne dihydropteroate synthases mediating bacterial resistance to sulfonamides.

Authors:  G Swedberg; O Sköld
Journal:  J Bacteriol       Date:  1980-04       Impact factor: 3.490
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