| Literature DB >> 11012033 |
Y Okada1, Y Tsuda, K Wanaka, M Tada, U Okamoto, S Okamoto, A Hijikata-Okunomiya, G Bokonyi, B Szende, G Keri.
Abstract
trans-4-Aminomethylcyclohexanecarbonyl-Tyr(O-Pic)-octylamide (YO-2) inhibited plasmin (PL) selectively, while trans-4-aminomethylcyclohexanecarbonyl-Phe-4-carboxymethylanili de (YO-1) inhibited plasma kallikrein (PK). YO-2 induced apoptosis of M1 (melanoma) cell line and HT29 colon carcinoma cells during 24 h through activation of caspase-3, while YO-1 did not affect either cell line even during 48 h.Entities:
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Year: 2000 PMID： 11012033 DOI： 10.1016/s0960-894x(00)00431-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823