Literature DB >> 11012032

Biologically active oligodeoxyribonucleotides. Part 12: N2-methylation of 2'-deoxyguanosines enhances stability of parallel G-quadruplex and anti-HIV-1 activity.

M Koizumi1, K Akahori, T Ohmine, S Tsutsumi, J Sone, T Kosaka, M Kaneko, S Kimura, K Shimada.   

Abstract

2'-Deoxyguanosine residues of a 3',5'-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N2-methyl-2'-deoxyguanosine (m2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs indicated that the m2dG modification stabilized the tertiary structure of the G-quadruplex.

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Year:  2000        PMID： 11012032     DOI： 10.1016/s0960-894x(00)00432-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  DNA duplexes with hydrophobic modifications inhibit fusion between HIV-1 and cell membranes.

Authors:  Liang Xu; Lifeng Cai; Xueliang Chen; Xifeng Jiang; Huihui Chong; Baohua Zheng; Kun Wang; Junlin He; Wei Chen; Tao Zhang; Maosheng Cheng; Yuxian He; Keliang Liu
Journal:  Antimicrob Agents Chemother       Date:  2013-07-29       Impact factor: 5.191

Review 2.  In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

Authors:  Janos Sagi
Journal:  J Nucleic Acids       Date:  2017-10-18

3.  Synthesis and characterization of modified nucleotides in the 970 hairpin loop of Escherichia coli 16S ribosomal RNA.

Authors:  N Dinuka Abeydeera; Christine S Chow
Journal:  Bioorg Med Chem       Date:  2009-07-09       Impact factor: 3.641

4.  Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure.

Authors:  Jun Chen; Liang Ren Zhang; Ji Mei Min; Li He Zhang
Journal:  Nucleic Acids Res       Date:  2002-07-01       Impact factor: 16.971

5.  Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality.

Authors:  Antonella Virgilio; Annapina Russo; Teresa Amato; Giulia Russo; Luciano Mayol; Veronica Esposito; Aldo Galeone
Journal:  Nucleic Acids Res       Date:  2017-08-21       Impact factor: 16.971

6.  Ball with hair: modular functionalization of highly stable G-quadruplex DNA nano-scaffolds through N2-guanine modification.

Authors:  Christopher Jacques Lech; Anh Tuân Phan
Journal:  Nucleic Acids Res       Date:  2017-06-20       Impact factor: 16.971

7.  Sugar-modified G-quadruplexes: effects of LNA-, 2'F-RNA- and 2'F-ANA-guanosine chemistries on G-quadruplex structure and stability.

Authors:  Zhe Li; Christopher Jacques Lech; Anh Tuân Phan
Journal:  Nucleic Acids Res       Date:  2013-12-25       Impact factor: 16.971
  7 in total

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