Literature DB >> 11012029

Interaction of cyanine dyes with nucleic acids. Part 19: new method for the covalent labeling of oligonucleotides with pyrylium cyanine dyes.

S M Yarmoluk1, A M Kostenko, I Y Dubey.   

Abstract

New chemistry for the fluorescent labeling of oligonucleotides with cyanine dyes is proposed. It is based on the use of pyrylium salts as amine-specific reagents. Monomethyne pyrylium cyanine dye 1 was covalently linked to 5'-aminoalkyl modified oligonucleotide, with simultaneous conversion of the non-fluorescent dye 1 into fluorescent pyridinium cyanine structure 2.

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Year:  2000        PMID： 11012029     DOI： 10.1016/s0960-894x(00)00435-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  New method for covalent fluorescent biomolecule labeling with hemicyanine dye.

Authors:  Olexander M Kostenko; Vladyslava B Kovalska; Kateryna D Volkova; Pavel Shaytanov; Igor O Kocheshev; Yuriy L Slominskiy; Irina V Pisareva; Sergiy M Yarmoluk
Journal:  J Fluoresc       Date:  2006-06-15       Impact factor: 2.217

2.  Tumor targeting, trifunctional dendritic wedge.

Authors:  Ramin Dubey; Swati Kushal; Alexis Mollard; Lesya Vojtovich; Philip Oh; Michael D Levin; Jan E Schnitzer; Ilya Zharov; Bogdan Z Olenyuk
Journal:  Bioconjug Chem       Date:  2014-11-12       Impact factor: 6.069
  2 in total

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