Heparinisation in chronic haemodialysis treatment: bolus injection or continuous homogeneous infusion?

After several incidents where patients either bled after dialysis or suffered severe anaphylactic reactions caused by intravenous heparin injections, we decided to administer heparin as a continuous homogeneous intravenous infusion. This had been usual practice in our unit in the past. Following the shocking experience of the death of a patient due to an anaphylactic reaction during his first dialysis, we wanted to warn colleagues for the potential dangers of administering intravenous heparin as a bolus injection.