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Literature DB >> 11010912

Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum.

M van de Kamp¹, T A Schuurs, A Vos, T R van der Lende, W N Konings, A J Driessen.

Abstract

Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.

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Year: 2000 PMID： 11010912 PMCID： PMC92338 DOI： 10.1128/AEM.66.10.4536-4538.2000

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

20 in total

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3 in total