Literature DB >> 11009362

Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.

R M Garbaccio1, S J Danishefsky.   

Abstract

A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a vinyl epoxide.

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Year:  2000        PMID: 11009362     DOI: 10.1021/ol0063252

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  3 in total

1.  Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation.

Authors:  Yiyang Luo; Xianglin Yin; Mingji Dai
Journal:  J Antibiot (Tokyo)       Date:  2019-02-13       Impact factor: 2.649

2.  Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.

Authors:  Thomas J Turbyville; E M Kithsiri Wijeratne; Manping X Liu; Anna M Burns; Christopher J Seliga; Libia A Luevano; Cynthia L David; Stanley H Faeth; Luke Whitesell; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2006-02       Impact factor: 4.050

Review 3.  Natural and Synthetic Lactones Possessing Antitumor Activities.

Authors:  Younghoon Kim; Sandip Sengupta; Taebo Sim
Journal:  Int J Mol Sci       Date:  2021-01-21       Impact factor: 6.208

  3 in total

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