| Literature DB >> 11009146 |
J M MacLennan, R Urwin, S Obaro, D Griffiths, B Greenwood, M C Maiden.
Abstract
We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30-40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0.5-1.0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.Entities:
Keywords: Africa; Africa South Of The Sahara; Biology; Central Nervous System; Central Nervous System Effects; Clinical Research; Clinical Trials; Cohort Analysis; Developing Countries; English Speaking Africa; Gambia; Physiology; Research Methodology; Research Report; Vaccines; Western Africa
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Year: 2000 PMID： 11009146 DOI： 10.1016/S0140-6736(00)02734-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321