Literature DB >> 11007962

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1.

S Pyronnet1.   

Abstract

The purpose of this review is to summarize recent experimental data describing the regulation of the phosphorylation of eIF4E, the cap-binding protein, by the MAPK-activated protein kinase Mnk1. Mnk1 does not interact directly with eIF4E, but uses a docking site in eIF4G, a partner of eIF4E. Consequently, control of eIF4E phosphorylation may not strictly depend on changes in Mnk1 activity. The possibility that integrity of the eIF4E/eIF4G/Mnk1 complex also impinges upon eIF4E phosphorylation is discussed.

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Year:  2000        PMID： 11007962     DOI： 10.1016/s0006-2952(00)00429-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  37 in total

1.  Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.

Authors:  Yikun Li; Ping Yue; Xingming Deng; Takeshi Ueda; Rikiro Fukunaga; Fadlo R Khuri; Shi-Yong Sun
Journal:  Neoplasia       Date:  2010-10       Impact factor: 5.715

2.  Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation.

Authors:  Jeffrey S Shenberger; Lianqin Zhang; Mariah K Hughlock; Takeshi Ueda; Rie Watanabe-Fukunaga; Rikiro Fukunaga
Journal:  Int J Biochem Cell Biol       Date:  2007-05-10       Impact factor: 5.085

Review 3.  Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.

Authors:  Anthony Wayne Orr; Nicole E Hastings; Brett R Blackman; Brian R Wamhoff
Journal:  J Vasc Res       Date:  2009-10-22       Impact factor: 1.934

4.  The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

Authors:  G C Scheper; N A Morrice; M Kleijn; C G Proud
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

5.  Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

Authors:  Takeshi Ueda; Masato Sasaki; Andrew J Elia; Iok In Christine Chio; Koichi Hamada; Rikiro Fukunaga; Tak W Mak
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

6.  Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.

Authors:  Takeshi Ueda; Rie Watanabe-Fukunaga; Hidehiro Fukuyama; Shigekazu Nagata; Rikiro Fukunaga
Journal:  Mol Cell Biol       Date:  2004-08       Impact factor: 4.272

7.  A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.

Authors:  Raghu S Nagalingam; Nagalingam R Sundaresan; Mahesh P Gupta; David L Geenen; R John Solaro; Madhu Gupta
Journal:  J Biol Chem       Date:  2013-02-27       Impact factor: 5.157

Review 8.  Enhancing mTOR-targeted cancer therapy.

Authors:  Xuerong Wang; Shi-Yong Sun
Journal:  Expert Opin Ther Targets       Date:  2009-10       Impact factor: 6.902

9.  Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.

Authors:  Grégory Caignard; Anastassia V Komarova; Mehdi Bouraï; Thomas Mourez; Yves Jacob; Louis M Jones; Flore Rozenberg; Astrid Vabret; François Freymuth; Frédéric Tangy; Pierre-Olivier Vidalain
Journal:  PLoS Pathog       Date:  2009-09-18       Impact factor: 6.823

10.  An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.

Authors:  Wenge Li; Nehal Thakor; Eugenia Y Xu; Ying Huang; Chi Chen; Rong Yu; Martin Holcik; Ah-Ng Kong
Journal:  Nucleic Acids Res       Date:  2009-11-24       Impact factor: 16.971
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