OBJECTIVE: To examine neurocognitive functioning in children classified with overt cerebral vascular accidents (CVAs), silent infarcts, or without central nervous system (CNS) pathology on magnetic resonance imaging. METHODS: Participants were 63 children and adolescents with sickle cell disease (SCD). RESULTS: Children with overt CVAs and silent infarcts differed from their peers without CNS pathology on measures of attention and executive functioning. CONCLUSIONS: We consider these deficits the result of the high frequency of frontal lobe deficits incurred by children with SCD. Recommendations include the use of tests designed to measure attention and executive functioning as a way of screening children with SCD for possible CNS pathology. We also suggest that future research examine the mechanism underlying frontal lobe involvement for individuals with SCD.
OBJECTIVE: To examine neurocognitive functioning in children classified with overt cerebral vascular accidents (CVAs), silent infarcts, or without central nervous system (CNS) pathology on magnetic resonance imaging. METHODS:Participants were 63 children and adolescents with sickle cell disease (SCD). RESULTS:Children with overt CVAs and silent infarcts differed from their peers without CNS pathology on measures of attention and executive functioning. CONCLUSIONS: We consider these deficits the result of the high frequency of frontal lobe deficits incurred by children with SCD. Recommendations include the use of tests designed to measure attention and executive functioning as a way of screening children with SCD for possible CNS pathology. We also suggest that future research examine the mechanism underlying frontal lobe involvement for individuals with SCD.
Authors: Olubusola B Oluwole; Robert B Noll; Daniel G Winger; Olu Akinyanju; Enrico M Novelli Journal: Pediatr Blood Cancer Date: 2016-07-09 Impact factor: 3.167
Authors: Brian Daly; Mary C Kral; Ronald T Brown; David Elkin; Avi Madan-Swain; Monica Mitchell; Lori Crosby; David Dematteo; Angela Larosa; Sherron Jackson Journal: J Dev Behav Pediatr Date: 2012-04 Impact factor: 2.225
Authors: Janet Yarboi; Kemar V Prussien; Heather Bemis; Ellen Williams; Kelly H Watson; Collen McNally; Lauren Henry; Allison A King; Michael R DeBaun; Bruce E Compas Journal: J Pediatr Psychol Date: 2019-11-01