Literature DB >> 11007490

A neocentromere in the DAZ region of the human Y chromosome.

G Floridia1, G Gimelli, O Zuffardi, W C Earnshaw, P E Warburton, C Tyler-Smith.   

Abstract

We describe a novel rearranged human Y chromosome consisting of an inverted duplication of the long arm heterochromatin and a small amount of euchromatin: rea(Y)(qter-q11.2::q11.2-qter). The normal centromere has been deleted and a neocentromere containing CENP-A, -C, -E and Mad2 but not CENP-B has formed close to the breakpoint. A 2.7 Mb yeast artificial chromosome contig spanning the breakpoint was constructed and the breakpoint was localised to a region of <120 kb close to the DAZ gene cluster. Combined immunofluorescence and fluorescence in situ hybridisation showed that the centromeric protein-binding domain of the neocentromere was located near the breakpoint and within the DAZ cluster.

Entities:  

Mesh：

Year:  2000        PMID： 11007490     DOI： 10.1007/s004120000081

Source DB:  PubMed          Journal:  Chromosoma        ISSN： 0009-5915            Impact factor:   4.316


  8 in total

1.  Mapping of a human centromere onto the DNA by topoisomerase II cleavage.

Authors:  G Floridia; A Zatterale; O Zuffardi; C Tyler-Smith
Journal:  EMBO Rep       Date:  2000-12       Impact factor: 8.807

2.  Progressive proximal expansion of the primate X chromosome centromere.

Authors:  Mary G Schueler; John M Dunn; Christine P Bird; Mark T Ross; Luigi Viggiano; Mariano Rocchi; Huntington F Willard; Eric D Green
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-19       Impact factor: 11.205

Review 3.  Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution.

Authors:  Owen J Marshall; Anderly C Chueh; Lee H Wong; K H Andy Choo
Journal:  Am J Hum Genet       Date:  2008-02       Impact factor: 11.025

4.  Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK.

Authors:  Santiago Rodríguez; Xiao-He Chen; George J Miller; Ian N M Day
Journal:  Hum Genet       Date:  2005-01-27       Impact factor: 4.132

Review 5.  Satellite DNAs and human sex chromosome variation.

Authors:  Monika Cechova; Karen H Miga
Journal:  Semin Cell Dev Biol       Date:  2022-05-27       Impact factor: 7.499

6.  A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.

Authors:  S Fernandes; S Paracchini; L H Meyer; G Floridia; C Tyler-Smith; P H Vogt
Journal:  Am J Hum Genet       Date:  2003-11-21       Impact factor: 11.025

Review 7.  Neocentromeres: role in human disease, evolution, and centromere study.

Authors:  David J Amor; K H Andy Choo
Journal:  Am J Hum Genet       Date:  2002-08-26       Impact factor: 11.025

Review 8.  The unconventional structure of centromeric nucleosomes.

Authors:  Steven Henikoff; Takehito Furuyama
Journal:  Chromosoma       Date:  2012-05-03       Impact factor: 4.316
  8 in total

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