Literature DB >> 11007361

Cytokine-secreting tumor cell vaccines.

N Mach1, G Dranoff.   

Abstract

Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

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Year:  2000        PMID： 11007361     DOI： 10.1016/s0952-7915(00)00144-8

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  27 in total

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Review 9.  Tumor vaccines for breast cancer.

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10.  Induction of an antitumour adaptive immune response elicited by tumour cells expressing de novo B7-1 mainly depends on the anatomical site of their delivery: the dose applied regulates the expansion of the response.

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Journal:  Immunology       Date:  2003-12       Impact factor: 7.397
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