Literature DB >> 11006983

Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation.

M Chopp1, X H Zhang, Y Li, L Wang, J Chen, D Lu, M Lu, M Rosenblum.   

Abstract

We tested the hypothesis that transplantation of bone marrow stromal cells (MSCs) into the spinal cord after a contusion injury promotes functional outcome. Rats (n = 31) were subjected to a weight driven implant injury. MSCs or phosphate buffered saline was injected into the spinal cord 1 week after injury. Sections of tissue were analyzed by double-labeled immunohistochemistry for MSC identification. Functional outcome measurements using the Basso-Beattie-Bresnehan score were performed weekly to 5 weeks post-injury. The data indicate significant improvement in functional outcome in animals treated with MSC transplantation compared to control animals. Scattered cells derived from MSCs expressed neural protein markers. These data suggest that transplantation of MSCs may have a therapeutic role after spinal cord injury.

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Year:  2000        PMID： 11006983     DOI： 10.1097/00001756-200009110-00035

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  128 in total

1.  Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery.

Authors:  C P Hofstetter; E J Schwarz; D Hess; J Widenfalk; A El Manira; Darwin J Prockop; L Olson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

2.  Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells.

Authors:  D C Colter; I Sekiya; D J Prockop
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-26       Impact factor: 11.205

Review 3.  Bone marrow stem cells and polymer hydrogels--two strategies for spinal cord injury repair.

Authors:  Eva Syková; Pavla Jendelová; Lucia Urdzíková; Petr Lesný; Ales Hejcl
Journal:  Cell Mol Neurobiol       Date:  2006-04-22       Impact factor: 5.046

Review 4.  One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.

Authors:  Darwin J Prockop; Carl A Gregory; Jeffery L Spees
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-17       Impact factor: 11.205

5.  Remyelination of the spinal cord following intravenous delivery of bone marrow cells.

Authors:  Yukinori Akiyama; Christine Radtke; Osamu Honmou; Jeffery D Kocsis
Journal:  Glia       Date:  2002-09       Impact factor: 7.452

6.  Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells.

Authors:  Yukinori Akiyama; Christine Radtke; Jeffery D Kocsis
Journal:  J Neurosci       Date:  2002-08-01       Impact factor: 6.167

Review 7.  Cell therapy in demyelinating diseases.

Authors:  Claire Rice; Christopher Halfpenny; Neil Scolding
Journal:  NeuroRx       Date:  2004-10

8.  Mitochondrial transfer between cells can rescue aerobic respiration.

Authors:  Jeffrey L Spees; Scott D Olson; Mandolin J Whitney; Darwin J Prockop
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

9.  Comparison of transplantation of bone marrow stromal cells (BMSC) and stem cell mobilization by granulocyte colony stimulating factor after traumatic brain injury in rat.

Authors:  Mehrdad Bakhtiary; Mohsen Marzban; Mehdi Mehdizadeh; Mohammad Taghi Joghataei; Samideh Khoei; Vahid Pirhajati Mahabadi; Bahareh Laribi; Mahdi Tondar; Arash Moshkforoush
Journal:  Iran Biomed J       Date:  2010-10

10.  Intranasal delivery of central nervous system-retargeted human mesenchymal stromal cells prolongs treatment efficacy of experimental autoimmune encephalomyelitis.

Authors:  Moa Fransson; Elena Piras; Hao Wang; Joachim Burman; Ida Duprez; Robert A Harris; Katarina LeBlanc; Peetra U Magnusson; Eva Brittebo; Angelica S I Loskog
Journal:  Immunology       Date:  2014-07       Impact factor: 7.397
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