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Literature DB >> 11006977

p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus.

M Djebaïli¹, G Rondouin, V Baille, J Bockaert.

Abstract

Seven days after in vivo intrahippocampal administration of NMDA, 3'-OH DNA fragmentations and Bax protein expression were detected in hippocampal neurons of p53+/+ but not p53-/- transgenic mice. Interestingly, neurons showing pycnosis, an early apoptotic phenomena, were present in all genotypes. These results confirm that apoptotic 3'OH DNA fragmentations and Bax protein induction during NMDA-induced apoptosis in adult hippocampal neurons are p53 dependent.

Entities: Chemical Gene Species

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Year: 2000 PMID： 11006977 DOI： 10.1097/00001756-200009110-00029

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

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Cited

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8 in total

p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus.

1. Emerging roles of p53 in glial cell function in health and disease.

2. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

3. Telomerase deficiency affects normal brain functions in mice.

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6. Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment.

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8. Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells.