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Literature DB >> 11006546

Modular evolution of the purine biosynthetic pathway.

Abstract

Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.

Entities: Chemical

Mesh：

Substances：
Proteins
Purines

Year: 2000 PMID： 11006546 DOI： 10.1016/s1367-5931(00)00133-2

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

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Cited

34 in total

1. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.

Authors: Jérôme Le Nours; Esther M M Bulloch; Zhening Zhang; David R Greenwood; Martin J Middleditch; James M J Dickson; Edward N Baker
Journal: J Biol Chem Date: 2011-09-28 Impact factor: 5.157

2. Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA.

Authors: Bo Pang; Jose L McFaline; Nicholas E Burgis; Min Dong; Koli Taghizadeh; Matthew R Sullivan; C Eric Elmquist; Richard P Cunningham; Peter C Dedon
Journal: Proc Natl Acad Sci U S A Date: 2012-01-30 Impact factor: 11.205

Modular evolution of the purine biosynthetic pathway.

1. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.

2. Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA.

3. Divergence of de novo biosynthesis of inosine-5'-triphosphate.

Review 4. On the origin of biochemistry at an alkaline hydrothermal vent.

5. Structural and functional modularity of proteins in the de novo purine biosynthetic pathway.

6. Role of purine biosynthesis in Bacillus anthracis pathogenesis and virulence.

7. Metabolic engineering of the purine pathway for riboflavin production in Ashbya gossypii.

8. Withdrawn

9. No Evidence for Mutations that Deregulate GARS-AIRS-GART Protein Levels in Children with Down Syndrome.

10. Pathway engineered enzymatic de novo purine nucleotide synthesis.