PURPOSE: To reconstruct the transcriptional profile of the human adult retina and the genomic map of the genes expressed in this tissue. METHODS: Original software was used for the retrieval and analysis of records from UniGene (http://www.ncbi.nlm.nih. gov/UniGene/) pertaining to selected cDNA libraries from adult human retina. RESULTS: The 4974 genes reported so far to be expressed in retina were included in a catalog available on the Internet. For each entry, an estimation of the level of expression of the corresponding gene in the retina was provided. A high-resolution genomic map of the human retina was built up by inclusion of 3152 genes showing a precise and unique map assignment. The correspondence was established between 53 gene-orphan retinal diseases and clusters of genes expressed in the retina. CONCLUSIONS: The in silico reconstruction of the transcriptional profile of the adult human retina provides preliminary information on the pattern of genomic expression in this tissue. The chromosomal location of many retinal genes, combined with their expression data, should speed up the identification of genes involved in retinal diseases.
PURPOSE: To reconstruct the transcriptional profile of the human adult retina and the genomic map of the genes expressed in this tissue. METHODS: Original software was used for the retrieval and analysis of records from UniGene (http://www.ncbi.nlm.nih. gov/UniGene/) pertaining to selected cDNA libraries from adult human retina. RESULTS: The 4974 genes reported so far to be expressed in retina were included in a catalog available on the Internet. For each entry, an estimation of the level of expression of the corresponding gene in the retina was provided. A high-resolution genomic map of the human retina was built up by inclusion of 3152 genes showing a precise and unique map assignment. The correspondence was established between 53 gene-orphan retinal diseases and clusters of genes expressed in the retina. CONCLUSIONS: The in silico reconstruction of the transcriptional profile of the adult human retina provides preliminary information on the pattern of genomic expression in this tissue. The chromosomal location of many retinal genes, combined with their expression data, should speed up the identification of genes involved in retinal diseases.
Authors: Mari Cleide Sogayar; Anamaria A Camargo; Fabiana Bettoni; Dirce Maria Carraro; Lilian C Pires; Raphael B Parmigiani; Elisa N Ferreira; Eloísa de Sá Moreira; Maria do Rosário D de O Latorre; Andrew J G Simpson; Luciana Oliveira Cruz; Theri Leica Degaki; Fernanda Festa; Katlin B Massirer; Mari C Sogayar; Fernando Camargo Filho; Luiz Paulo Camargo; Marco A V Cunha; Sandro J De Souza; Milton Faria; Silvana Giuliatti; Leonardo Kopp; Paulo S L de Oliveira; Paulo B Paiva; Anderson A Pereira; Daniel G Pinheiro; Renato D Puga; Jorge Estefano S de Souza; Dulcineia M Albuquerque; Luís E C Andrade; Gilson S Baia; Marcelo R S Briones; Ana M S Cavaleiro-Luna; Janete M Cerutti; Fernando F Costa; Eugenia Costanzi-Strauss; Enilza M Espreafico; Adriana C Ferrasi; Emer S Ferro; Maria A H Z Fortes; Joelma R F Furchi; Daniel Giannella-Neto; Gustavo H Goldman; Maria H S Goldman; Arthur Gruber; Gustavo S Guimarães; Christine Hackel; Flavio Henrique-Silva; Edna T Kimura; Suzana G Leoni; Cláudia Macedo; Bettina Malnic; Carina V Manzini B; Suely K N Marie; Nilce M Martinez-Rossi; Marcelo Menossi; Elisabete C Miracca; Maria A Nagai; Francisco G Nobrega; Marina P Nobrega; Sueli M Oba-Shinjo; Márika K Oliveira; Guilherme M Orabona; Audrey Y Otsuka; Maria L Paço-Larson; Beatriz M C Paixão; Jose R C Pandolfi; Maria I M C Pardini; Maria R Passos Bueno; Geraldo A S Passos; Joao B Pesquero; Juliana G Pessoa; Paula Rahal; Cláudia A Rainho; Caroline P Reis; Tatiana I Ricca; Vanderlei Rodrigues; Silvia R Rogatto; Camila M Romano; Janaína G Romeiro; Antonio Rossi; Renata G Sá; Magaly M Sales; Simone C Sant'Anna; Patrícia L Santarosa; Fernando Segato; Wilson A Silva; Ismael D C G Silva; Neusa P Silva; Andrea Soares-Costa; Maria F Sonati; Bryan E Strauss; Eloiza H Tajara; Sandro R Valentini; Fabiola E Villanova; Laura S Ward; Dalila L Zanette Journal: Genome Res Date: 2004-06-14 Impact factor: 9.043
Authors: Natalie E Freeman; Justin P Templeton; William E Orr; Lu Lu; Robert W Williams; Eldon E Geisert Journal: Mol Vis Date: 2011-05-25 Impact factor: 2.367
Authors: Michael H Farkas; Gregory R Grant; Joseph A White; Maria E Sousa; Mark B Consugar; Eric A Pierce Journal: BMC Genomics Date: 2013-07-18 Impact factor: 3.969