Literature DB >> 11005870

Rapid induction of senescence in human cervical carcinoma cells.

E C Goodwin1, E Yang, C J Lee, H W Lee, D DiMaio, E S Hwang.   

Abstract

Expression of the bovine papillomavirus E2 regulatory protein in human cervical carcinoma cell lines repressed expression of the resident human papillomavirus E6 and E7 oncogenes and within a few days caused essentially all of the cells to synchronously display numerous phenotypic markers characteristic of cells undergoing replicative senescence. This process was accompanied by marked but in some cases transient alterations in the expression of cell cycle regulatory proteins and by decreased telomerase activity. We propose that the human papillomavirus E6 and E7 proteins actively prevent senescence from occurring in cervical carcinoma cells, and that once viral oncogene expression is extinguished, the senescence program is rapidly executed. Activation of endogenous senescence pathways in cancer cells may represent an alternative approach to treat human cancers.

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Year:  2000        PMID： 11005870      PMCID： PMC27134          DOI： 10.1073/pnas.97.20.10978

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  49 in total

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Authors:  H Vaziri; S Benchimol
Journal:  Exp Gerontol       Date:  1996 Jan-Apr       Impact factor: 4.032

2.  Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.

Authors:  A J Klingelhutz; S A Barber; P P Smith; K Dyer; J K McDougall
Journal:  Mol Cell Biol       Date:  1994-02       Impact factor: 4.272

3.  Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.

Authors:  O Loughran; A Malliri; D Owens; P H Gallimore; M A Stanley; B Ozanne; M C Frame; E K Parkinson
Journal:  Oncogene       Date:  1996-08-01       Impact factor: 9.867

4.  Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.

Authors:  R D Steenbergen; J M Walboomers; C J Meijer; E M van der Raaij-Helmer; J N Parker; L T Chow; T R Broker; P J Snijders
Journal:  Oncogene       Date:  1996-09-19       Impact factor: 9.867

5.  The RNA component of human telomerase.

Authors:  J Feng; W D Funk; S S Wang; S L Weinrich; A A Avilion; C P Chiu; R R Adams; E Chang; R C Allsopp; J Yu
Journal:  Science       Date:  1995-09-01       Impact factor: 47.728

6.  Lipofuscin accumulation and ageing of fibroblasts.

Authors:  T von Zglinicki; E Nilsson; W D Döcke; U T Brunk
Journal:  Gerontology       Date:  1995       Impact factor: 5.140

7.  Telomerase activation by the E6 gene product of human papillomavirus type 16.

Authors:  A J Klingelhutz; S A Foster; J K McDougall
Journal:  Nature       Date:  1996-03-07       Impact factor: 49.962

8.  Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

Authors:  S N Khleif; J DeGregori; C L Yee; G A Otterson; F J Kaye; J R Nevins; P M Howley
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

9.  Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene.

Authors:  E S Hwang; L K Naeger; D DiMaio
Journal:  Oncogene       Date:  1996-02-15       Impact factor: 9.867

10.  Suppression of cellular proliferation by the papillomavirus E2 protein.

Authors:  J J Dowhanick; A A McBride; P M Howley
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103
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  79 in total

1.  RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells.

Authors:  Allison H S Hall; Kenneth A Alexander
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

2.  HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS.

Authors:  Katerina Strati; Paul F Lambert
Journal:  Expert Opin Med Diagn       Date:  2008-01-01

3.  Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein.

Authors:  Jasmin Fertey; José Hurst; Elke Straub; Astrid Schenker; Thomas Iftner; Frank Stubenrauch
Journal:  J Virol       Date:  2010-12-29       Impact factor: 5.103

4.  miR-29 and miR-30 regulate B-Myb expression during cellular senescence.

Authors:  Ivan Martinez; Demian Cazalla; Laura L Almstead; Joan A Steitz; Daniel DiMaio
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

5.  Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility.

Authors:  Monique A Morrison; Richard J Morreale; Shailaja Akunuru; Matthew Kofron; Yi Zheng; Susanne I Wells
Journal:  J Virol       Date:  2011-08-10       Impact factor: 5.103

6.  Functional divergence of Kaposi's sarcoma-associated herpesvirus and related gamma-2 herpesvirus thymidine kinases: novel cytoplasmic phosphoproteins that alter cellular morphology and disrupt adhesion.

Authors:  Michael B Gill; Jo-Ellen Murphy; Joyce D Fingeroth
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

7.  p53 and hTERT determine sensitivity to viral apoptosis.

Authors:  Marie L Nguyen; Rachel M Kraft; Martine Aubert; Edward Goodwin; Daniel DiMaio; John A Blaho
Journal:  J Virol       Date:  2007-09-12       Impact factor: 5.103

8.  The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs.

Authors:  Marc A Schneider; Konstanze D Scheffer; Timo Bund; Fatima Boukhallouk; Carsten Lambert; Cristina Cotarelo; Gert O Pflugfelder; Luise Florin; Gilles A Spoden
Journal:  J Virol       Date:  2013-02-06       Impact factor: 5.103

9.  Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment.

Authors:  Zhenhua Lin; Martina Bazzaro; Mei-Cheng Wang; Kwun C Chan; Shiwen Peng; Richard B S Roden
Journal:  Clin Cancer Res       Date:  2009-01-15       Impact factor: 12.531

10.  Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.

Authors:  Claudio Talora; Dennis C Sgroi; Christopher P Crum; G Paolo Dotto
Journal:  Genes Dev       Date:  2002-09-01       Impact factor: 11.361
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