| Literature DB >> 11003703 |
S Lien1, A Karlsen, G Klemetsdal, D I Våge, I Olsaker, H Klungland, M Aasland, B Heringstad, J Ruane, L Gomez-Raya.
Abstract
An autosomal genome scan for quantitative trait loci (QTL) affecting twinning rate was carried out in the Norwegian Cattle population. Suggestive QTL were detected on Chromosomes (Chr) 5, 7, 12, and 23. Among these, the QTL positions on both Chr 5 and Chr 23 are strongly supported by literature in the field. Our results also confirm previous mapping of a QTL for twinning to Chr 7, but definitely suggest a different location of the QTL on this chromosome. The most convincing QTL peak was observed for a region in the middle part of Chr 5 close to the insulin-like growth factor 1 (IGF1) gene. Since IGF1 plays an important role in the regulation of folliculogenesis, a mutation search was performed by sequencing more than 3.5 kb of the gene in actual families. The sequencing revealed three polymorphisms in noncoding regions of the gene that will be important in fine structure mapping and characterization of the QTL.Entities:
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Year: 2000 PMID： 11003703 DOI： 10.1007/s003350010180
Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957