Literature DB >> 11003551

A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn.

F Hallouin1, C Goupille, J Rocher, J Le Pendu.   

Abstract

Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn positive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The model should be useful for testing new anti-Tn or Sialyl-Tn vaccination protocols.

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Year:  1999        PMID： 11003551     DOI： 10.1023/a:1007199124074

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  9 in total

1.  A fully synthetic immunogen carrying a carcinoma-associated carbohydrate for active specific immunotherapy.

Authors:  R Lo-Man; S Bay; S Vichier-Guerre; E Dériaud; D Cantacuzène; C Leclerc
Journal:  Cancer Res       Date:  1999-04-01       Impact factor: 12.701

2.  Increase of rat colon carcinoma cells tumorigenicity by alpha(1-2) fucosyltransferase gene transfection.

Authors:  C Goupille; F Hallouin; K Meflah; J Le Pendu
Journal:  Glycobiology       Date:  1997-03       Impact factor: 4.313

3.  Analysis of factors associated with the tumorigenic potential of 12 tumor clones derived from a single rat colon adenocarcinoma.

Authors:  R Zennadi; L Garrigue; S Ringeard; A Ménoret; P Blanchardie; J Le Pendu
Journal:  Int J Cancer       Date:  1992-12-02       Impact factor: 7.396

Review 4.  Carbohydrate vaccines that induce antibodies against cancer. 2. Previous experience and future plans.

Authors:  P O Livingston; G Ragupathi
Journal:  Cancer Immunol Immunother       Date:  1997-10       Impact factor: 6.968

Review 5.  Carbohydrate vaccines that induce antibodies against cancer. 1. Rationale.

Authors:  P O Livingston; S Zhang; K O Lloyd
Journal:  Cancer Immunol Immunother       Date:  1997-10       Impact factor: 6.968

6.  Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen.

Authors:  S gata; A Chen; S H Itzkowitz
Journal:  Cancer Res       Date:  1994-08-01       Impact factor: 12.701

7.  Interaction between two cellular subpopulations of a rat colonic carcinoma when inoculated to the syngeneic host.

Authors:  A Caignard; M S Martin; M F Michel; F Martin
Journal:  Int J Cancer       Date:  1985-08-15       Impact factor: 7.396

8.  Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium.

Authors:  J R Jass; L J Allison; S G Edgar
Journal:  J Pathol       Date:  1995-06       Impact factor: 7.996

9.  Induction of alpha-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice.

Authors:  A Singhal; M Fohn; S Hakomori
Journal:  Cancer Res       Date:  1991-03-01       Impact factor: 12.701
  9 in total
  2 in total

1.  Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.

Authors:  Jochen Gaedcke; Marian Grade; Klaus Jung; Jordi Camps; Peter Jo; Georg Emons; Anastasia Gehoff; Ulrich Sax; Markus Schirmer; Heinz Becker; Tim Beissbarth; Thomas Ried; B Michael Ghadimi
Journal:  Genes Chromosomes Cancer       Date:  2010-11       Impact factor: 5.006

2.  A rat model to study the role of STn antigen in colon cancer.

Authors:  S Ogata; I Ho; J Maklansky; A Chen; J L Werther; M Reddish; B M Longenecker; E Sigurdson; S Iishi; J Y Zhang; S H Itzkowitz
Journal:  Glycoconj J       Date:  2001 Nov-Dec       Impact factor: 2.916
  2 in total

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