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Literature DB >> 11003129

Chemistry and clinical biology of the bryostatins.

Abstract

Bryostatins are a class of antineoplastic compounds isolated from the bryozoans Bugula neritina. A wide range of scientific research is currently underway, studying different aspects of the bryostatins. In this review we try to summarize the latest findings, including all the topics involved, from marine biology to medicinal chemistry.

Entities: Chemical Species

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Year: 2000 PMID： 11003129 DOI： 10.1016/s0968-0896(00)00150-4

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

38 in total

1. A randomized phase II evaluation of bryostatin-1 (NSC #339555) in persistent or recurrent squamous cell carcinoma of the cervix: A Gynecologic Oncology Group Study.

Authors: Deborah K Armstrong; John A Blessing; Janet Rader; Joel I Sorosky
Journal: Invest New Drugs Date: 2003-11 Impact factor: 3.850

2. The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion.

Authors: Viola Biberacher; Thomas Decker; Madlen Oelsner; Michaela Wagner; Christian Bogner; Burkhard Schmidt; Robert J Kreitman; Christian Peschel; Ira Pastan; Christian Meyer Zum Büschenfelde; Ingo Ringshausen
Journal: Haematologica Date: 2011-12-16 Impact factor: 9.941

Review 10. Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.

Authors: Patrick C Still; Tyler A Johnson; Christine M Theodore; Steven T Loveridge; Phillip Crews
Journal: J Nat Prod Date: 2014-02-26 Impact factor: 4.050

Chemistry and clinical biology of the bryostatins.

1. A randomized phase II evaluation of bryostatin-1 (NSC #339555) in persistent or recurrent squamous cell carcinoma of the cervix: A Gynecologic Oncology Group Study.

2. The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion.

3. Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation.

4. Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ring.

Review 5. Drug development from marine natural products.

Review 6. Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery.

Review 7. Conformation-activity relationships of polyketide natural products.

8. "Candidatus Endobugula glebosa," a specific bacterial symbiont of the marine bryozoan Bugula simplex.

Review 9. Marine antitumor drugs: status, shortfalls and strategies.

Review 10. Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage.