Transcriptional regulation of liver development.

Over the last few years a number of transcription factors have been identified that have important roles in regulating liver development. Molecular analyses combined with molecular genetic approaches in the mouse have begun to unravel how these factors control specific aspects of hepatogenesis. The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation. Copyright 2000 Wiley-Liss, Inc.