| Literature DB >> 11000047 |
C R Weiss1, S V Moideen, S L Croft, P J Houghton.
Abstract
Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC(50) values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.Entities:
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Year: 2000 PMID： 11000047 DOI： 10.1021/np000029g
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050