| Literature DB >> 11000045 |
H F Smit1, A J van den Berg, B H Kroes, C J Beukelman, H C Quarles van Ufford, H van Dijk, R P Labadie.
Abstract
Two cucurbitacin aglycons were isolated from the dried rhizomes of Picrorhiza scrophulariaeflora and were identified as 25-acetoxy-2,3, 16,20-tetrahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (picracin, 1) and 2,3,16,20,25-pentahydroxy-9-methyl-19-norlanosta-5, 23-dien-22-one (deacetylpicracin, 2). Both compounds inhibit mitogen-induced T-lymphocyte proliferation at an IC(50) value of 1 microM.Entities:
Mesh：
Substances：
Year: 2000 PMID： 11000045 DOI： 10.1021/np990215q
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050