| Literature DB >> 11000020 |
J Y Cho1, K U Baik, E S Yoo, K Yoshikawa, M H Park.
Abstract
Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-alpha and nitric oxide (NuOmicron) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.Entities:
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Year: 2000 PMID： 11000020 DOI： 10.1021/np9902791
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050