Literature DB >> 10999488

7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.

G Buckley1, N Cooper, H J Dyke, F Galleway, L Gowers, J C Gregory, D R Hannah, A F Haughan, P G Hellewell, H J Kendall, C Lowe, R Maxey, J G Montana, R Naylor, C L Picken, K A Runcie, V Sabin, B R Tuladhar, J B Warneck.   

Abstract

The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).

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Year:  2000        PMID: 10999488     DOI: 10.1016/s0960-894x(00)00426-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

Review 1.  ABCD of the phosphodiesterase family: interaction and differential activity in COPD.

Authors:  David M G Halpin
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2008
  1 in total

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