Literature DB >> 10999475

Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.

V A Vaillancourt1, M M Cudahy, S A Staley, R J Brideau, S J Conrad, M L Knechtel, N L Oien, J L Wieber, Y Yagi, M W Wathen.   

Abstract

ortho-Hydroxynaphthalene carboxamides have been identified as inhibitors of HCMV DNA polymerase. SAR investigations have demonstrated that both the amide and hydroxy functionalities are required for activity. Substitution on the naphthalene ring has led to inhibitors with submicromolar IC50s against HCMV polymerase. These compounds have been found to be >100-fold selective for inhibition of HCMV polymerase versus human alpha polymerase and display antiviral activity in a cell-based plaque reduction assay.

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Year:  2000        PMID： 10999475     DOI： 10.1016/s0960-894x(00)00402-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Cytomegalovirus antivirals and development of improved animal models.

Authors:  Alistair McGregor; K Yeon Choi
Journal:  Expert Opin Drug Metab Toxicol       Date:  2011-09-01       Impact factor: 4.481

2.  Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors.

Authors:  Nancee L Oien; Roger J Brideau; Todd A Hopkins; Janet L Wieber; Mary L Knechtel; John A Shelly; Robert A Anstadt; Peter A Wells; Roger A Poorman; Audris Huang; Vallerie A Vaillancourt; Terrance L Clayton; John A Tucker; Michael W Wathen
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

3.  Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription.

Authors:  Bingbing X Li; Kinrin Yamanaka; Xiangshu Xiao
Journal:  Bioorg Med Chem       Date:  2012-10-04       Impact factor: 3.641

4.  Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents.

Authors:  Darrell R Thomsen; Nancee L Oien; Todd A Hopkins; Mary L Knechtel; Roger J Brideau; Michael W Wathen; Fred L Homa
Journal:  J Virol       Date:  2003-02       Impact factor: 5.103

5.  Microwave-assisted synthesis of new substituted anilides of quinaldic acid.

Authors:  Pavel Bobal; Josef Sujan; Jan Otevrel; Ales Imramovsky; Zdenka Padelkova; Josef Jampilek
Journal:  Molecules       Date:  2012-01-31       Impact factor: 4.411

6.  Investigation of some benzoquinazoline and quinazoline derivatives as novel inhibitors of HCV-NS3/4A protease: biological, molecular docking and QSAR studies.

Authors:  Hatem A Abuelizz; Mohamed Marzouk; Ahmed H Bakheit; Rashad Al-Salahi
Journal:  RSC Adv       Date:  2020-09-30       Impact factor: 4.036

Review 7.  Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase.

Authors:  D Topalis; S Gillemot; R Snoeck; G Andrei
Journal:  Nucleic Acids Res       Date:  2016-09-29       Impact factor: 16.971
  7 in total

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