| Literature DB >> 10999468 |
J Dumas1, H Hatoum-Mokdad, R Sibley, B Riedl, W J Scott, M K Monahan, T B Lowinger, C Brennan, R Natero, T Turner, J S Johnson, R Schoenleber, A Bhargava, S M Wilhelm, T J Housley, G E Ranges, A Shrikhande.
Abstract
Inhibitors of the MAP kinase p38 are potentially useful for the treatment of arthritis and osteoporosis. Several 2,3-dichlorophenyl ureas were identified as small-molecule inhibitors of p38 by a combinatorial chemistry effort. Optimization for cellular potency led to the discovery of a new class of potent and selective p38 kinase inhibitors, exemplified by the 1-phenyl-5-pyrazolyl urea 7 (IC50 = 13 nM).Entities:
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Year: 2000 PMID： 10999468 DOI： 10.1016/s0960-894x(00)00272-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823