| Literature DB >> 10999467 |
J Dumas1, R Sibley, B Riedl, M K Monahan, W Lee, T B Lowinger, A M Redman, J S Johnson, J Kingery-Wood, W J Scott, R A Smith, M Bobko, R Schoenleber, G E Ranges, T J Housley, A Bhargava, S M Wilhelm, A Shrikhande.
Abstract
The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class.Entities:
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Year: 2000 PMID： 10999467 DOI： 10.1016/s0960-894x(00)00270-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823