Literature DB >> 10998597

Rho family GTPases: more than simple switches.

M Symons1, J Settleman.   

Abstract

Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.

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Year:  2000        PMID： 10998597     DOI： 10.1016/s0962-8924(00)01832-8

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  56 in total

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Review 4.  Small GTPases: versatile signaling switches in plants.

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Authors:  Tasuku Ueno; Björn H Falkenburger; Christopher Pohlmeyer; Takanari Inoue
Journal:  Sci Signal       Date:  2011-12-13       Impact factor: 8.192

6.  Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis.

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Journal:  Genetics       Date:  2003-11       Impact factor: 4.562

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Authors:  Vladimir Litvak; Donguha Tian; Shari Carmon; Sima Lev
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8.  Drosophila Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1.

Authors:  Michael A Spinner; David A Walla; Tory G Herman
Journal:  Genetics       Date:  2017-12-07       Impact factor: 4.562

9.  Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

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10.  Regulation of TLR4-mediated signaling by IBP/Def6, a novel activator of Rho GTPases.

Authors:  Qinzhong Chen; Sanjay Gupta; Alessandra B Pernis
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