Literature DB >> 10998452

Acute megakaryocytic leukaemia with acquired polysomy 21 and translocation t(1;21).

S Paulien1, M Busson-Le Coniat, R Berger.   

Abstract

Cytogenetic study of a young child with acute megakaryocytic leukaemia (AML-M7) has shown a karyotype with 49-50 chromosomes with one and two acquired extra chromosomes 21. Fluorescence in situ hybridization detected a minor clone with translocation t(1;21) and loss of a part of chromosome band 1p36. Trisomy and polysomy 21 are not uncommon in AML-M7. A more systematic search for chromosome 21 rearrangements in AML-M7 using FISH techniques is proposed.

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Year:  2000        PMID： 10998452     DOI： 10.1016/s0003-3995(00)01019-4

Source DB:  PubMed          Journal:  Ann Genet        ISSN： 0003-3995


  2 in total

1.  Biological and clinical features of trisomy 21 in adult patients with acute myeloid leukemia.

Authors:  Paolo Strati; Naval Daver; Farhad Ravandi; Naveen Pemmaraju; Sherry Pierce; Guillermo Garcia-Manero; Aziz Nazha; Tapan Kadia; Elias Jabbour; Gautam Borthakur; Stefan Faderl; Alfonso Quintas-Cardama; Hagop Kantarjian; Jorge Cortes
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2013-08-19

Review 2.  Rare Cytogenetic Abnormalities and Alteration of microRNAs in Acute Myeloid Leukemia and Response to Therapy.

Authors:  Mohammad Shahjahani; Elahe Khodadi; Mohammad Seghatoleslami; Javad Mohammadi Asl; Neda Golchin; Zeynab Deris Zaieri; Najmaldin Saki
Journal:  Oncol Rev       Date:  2015-03-09
  2 in total

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