Literature DB >> 10997585

Involvement of G-protein-activated inwardly rectifying K (GIRK) channels in opioid-induced analgesia.

K Ikeda1, T Kobayashi, T Kumanishi, H Niki, R Yano.   

Abstract

To investigate the role of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia, we compared the effects of opioids in wild-type and weaver mutant mice having mutant GIRK channels. In the tail-flick and hot-plate tests, weaver mutant mice displayed significantly lower analgesia after either morphine or (-)-U-50488 administration. These findings suggest that GIRK channel activation is important in the induction of analgesia by opioids.

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Year:  2000        PMID： 10997585     DOI： 10.1016/s0168-0102(00)00144-9

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  30 in total

1.  A pervasive mechanism for analgesia: activation of GIRK2 channels.

Authors:  Y A Blednov; M Stoffel; H Alva; R A Harris
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-19       Impact factor: 11.205

Review 2.  Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction.

Authors:  Jody Mayfield; Yuri A Blednov; R Adron Harris
Journal:  Int Rev Neurobiol       Date:  2015-06-22       Impact factor: 3.230

3.  Identification of a G-Protein-Independent Activator of GIRK Channels.

Authors:  Yulin Zhao; Peter Man-Un Ung; Gergely Zahoránszky-Kőhalmi; Alexey V Zakharov; Natalia J Martinez; Anton Simeonov; Ian W Glaaser; Ganesha Rai; Avner Schlessinger; Juan J Marugan; Paul A Slesinger
Journal:  Cell Rep       Date:  2020-06-16       Impact factor: 9.423

4.  Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR).

Authors:  Pavel Gris; Philip Cheng; John Pierson; William Maixner; Luda Diatchenko
Journal:  Methods Mol Biol       Date:  2010

Review 5.  Candidate gene polymorphisms predicting individual sensitivity to opioids.

Authors:  Shinya Kasai; Masakazu Hayashida; Ichiro Sora; Kazutaka Ikeda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-11-13       Impact factor: 3.000

Review 6.  Alcohol dependence as a chronic pain disorder.

Authors:  Mark Egli; George F Koob; Scott Edwards
Journal:  Neurosci Biobehav Rev       Date:  2012-09-11       Impact factor: 8.989

7.  G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.

Authors:  Atsushi Nakamura; Masahide Fujita; Hiroko Ono; Yoshie Hongo; Tomoe Kanbara; Koichi Ogawa; Yasuhide Morioka; Atsushi Nishiyori; Masahiro Shibasaki; Tomohisa Mori; Tsutomu Suzuki; Gaku Sakaguchi; Akira Kato; Minoru Hasegawa
Journal:  Br J Pharmacol       Date:  2014-01       Impact factor: 8.739

Review 8.  Modulation of pain transmission by G-protein-coupled receptors.

Authors:  Hui-Lin Pan; Zi-Zhen Wu; Hong-Yi Zhou; Shao-Rui Chen; Hong-Mei Zhang; De-Pei Li
Journal:  Pharmacol Ther       Date:  2007-09-22       Impact factor: 12.310

9.  Involvement of Gi/o proteins and GIRK channels in the potentiation of morphine-induced spinal analgesia in acutely inflamed mice.

Authors:  Sara González-Rodríguez; Agustín Hidalgo; Ana Baamonde; Luis Menéndez
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-11-26       Impact factor: 3.000

10.  Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery.

Authors:  Daisuke Nishizawa; Makoto Nagashima; Ryoji Katoh; Yasuo Satoh; Megumi Tagami; Shinya Kasai; Yasukazu Ogai; Wenhua Han; Junko Hasegawa; Naohito Shimoyama; Ichiro Sora; Masakazu Hayashida; Kazutaka Ikeda
Journal:  PLoS One       Date:  2009-09-16       Impact factor: 3.240
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