[The vasomotor effects of new fluorine-containing synthetic activators of ATP-dependent potassium channels].

The influence of new fluorine-containing activators of K+ channels on the vascular tone was investigated in vitro experiments on the guinea pig aorta. We exerted the identification of mechanisms of the action of these substances using the well-known ATP-sensitive K+ channel inhibitor--glibenclamid--and showed their dose-effect correlation. It was shown that new fluorine-containing activators of K+ channels--PF-5 and PF-10--are powerful vasodilator substances and PF-5 in concentration more than 0.1 mM exerts a distort of vascular reaction on the vasoconstriction.