Literature DB >> 10996571

An engineering view of pharmaceutical powder mixing.

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Abstract

Can the pharmaceutical industry learn anything from other powder processing industries? Although essential regulatory processes have ensured that the pharmaceutical industry is a leader in quality assurance, they have also led to a conservative approach to process technology. Conservatism is advantageous when the dosage form and profit margins are stable; however, for most other industries, form, price and quality of product are all subject to fickle customer requirements. Other powder industries have used a sequential questioning approach to elicit new technical responses to change. Perhaps the time is ripe for this to be introduced to the pharmaceutical industry?

Year:  2000        PMID: 10996571     DOI: 10.1016/s1461-5347(00)00283-2

Source DB:  PubMed          Journal:  Pharm Sci Technol Today        ISSN: 1461-5347


  5 in total

1.  Monitoring blending of pharmaceutical powders with multipoint NIR spectroscopy.

Authors:  Otto Scheibelhofer; Nikolaus Balak; Patrick R Wahl; Daniel M Koller; Benjamin J Glasser; Johannes G Khinast
Journal:  AAPS PharmSciTech       Date:  2012-12-21       Impact factor: 3.246

2.  Preparation and characterization of highly porous direct compression carrier particles with improved drug loading during an interactive mixing process.

Authors:  Mingna Song; Ning Li; Louwrens R Tiedt; Michael D Degennaro; Melgardt M de Villiers
Journal:  AAPS PharmSciTech       Date:  2010-04-23       Impact factor: 3.246

3.  Spherical Agglomerates of Lactose Reduce Segregation in Powder Blends and Improve Uniformity of Tablet Content at High Drug Loads.

Authors:  Dejan Lamešić; Blaž Grilc; Robert Roškar; Selina Kolokytha; Jürgen Hofmann; Andreas Malekos; Rolf Kaufmann; Odon Planinšek
Journal:  AAPS PharmSciTech       Date:  2021-12-10       Impact factor: 3.246

4.  An investigation into the effects of excipient particle size, blending techniques and processing parameters on the homogeneity and content uniformity of a blend containing low-dose model drug.

Authors:  Hamad Alyami; Eman Dahmash; James Bowen; Afzal R Mohammed
Journal:  PLoS One       Date:  2017-06-13       Impact factor: 3.240

5.  Impact of Mixing on Content Uniformity of Thin Polymer Films Containing Drug Micro-Doses.

Authors:  Guluzar G Buyukgoz; Jeremiah N Castro; Andrew E Atalla; John G Pentangelo; Siddharth Tripathi; Rajesh N Davé
Journal:  Pharmaceutics       Date:  2021-05-29       Impact factor: 6.321

  5 in total

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