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Literature DB >> 10996156

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.

W F Maragos¹, R Jakel, D Chesnut, C B Pocernich, D A Butterfield, D St Clair, W A Cass.

Abstract

We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration.

Entities: Chemical Disease Gene Species

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Year: 2000 PMID： 10996156 DOI： 10.1016/s0006-8993(00)02707-4

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

21 in total

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3. Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease.

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Review 4. Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review.

Authors: Eun-Joo Shin; Hai-Quyen Tran; Phuong-Tram Nguyen; Ji Hoon Jeong; Seung-Yeol Nah; Choon-Gon Jang; Toshitaka Nabeshima; Hyoung-Chun Kim
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10. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells.

Authors: J Tangpong; P Sompol; M Vore; W St Clair; D A Butterfield; D K St Clair
Journal: Neuroscience Date: 2007-11-13 Impact factor: 3.590

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.

Review 1. Reactive oxygen species in the regulation of synaptic plasticity and memory.

2. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

3. Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease.

Review 4. Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review.

5. Attenuation of cocaine and methamphetamine neurotoxicity by coenzyme Q10.

6. Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum.

Review 7. Nucleus accumbens invulnerability to methamphetamine neurotoxicity.

8. Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains.

9. Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice.

10. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells.