Literature DB >> 10995582

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.

D R Alexander1.   

Abstract

The CD45 phosphotyrosine phosphatase is one of the most abundant glycoproteins expressed on immune cells. Previously, the serpentine twists and turns of the CD45 research field have tended to draw attention to CD45 either as a positive or negative regulator of immune cell function. This review draws heavily on CD45 knockout mouse data to emphasize that CD45 has both positive and negative actions in regulating receptor thresholds, and these roles vary according to cell lineage and developmental stage. Previously conflicting results are reconciled in a model suggesting how CD45 regulates the p56(lck)tyrosine kinase in T cell signalling and development. Copyright 2000 Academic Press.

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Year:  2000        PMID： 10995582     DOI： 10.1006/smim.2000.0218

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  27 in total

Review 1.  Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases.

Authors:  Michelle L Hermiston; Zheng Xu; Ravindra Majeti; Arthur Weiss
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

Review 2.  Structural and evolutionary relationships among protein tyrosine phosphatase domains.

Authors:  J N Andersen; O H Mortensen; G H Peters; P G Drake; L F Iversen; O H Olsen; P G Jansen; H S Andersen; N K Tonks; N P Møller
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

3.  Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.

Authors:  M Baker; J Gamble; R Tooze; D Higgins; F T Yang; P C O'Brien; N Coleman; S Pingel; M Turner; D R Alexander
Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

Review 4.  CD45: all is not yet crystal clear.

Authors:  Nick Holmes
Journal:  Immunology       Date:  2006-02       Impact factor: 7.397

5.  Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters.

Authors:  Gabriela Furlan; Takashi Minowa; Nobutaka Hanagata; Chiho Kataoka-Hamai; Yoshihisa Kaizuka
Journal:  J Biol Chem       Date:  2014-08-15       Impact factor: 5.157

Review 6.  Insights into the initiation of TCR signaling.

Authors:  Arup K Chakraborty; Arthur Weiss
Journal:  Nat Immunol       Date:  2014-09       Impact factor: 25.606

7.  Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.

Authors:  Anne Kresinsky; Tina M Schnöder; Ilse D Jacobsen; Martina Rauner; Lorenz C Hofbauer; Volker Ast; Rainer König; Bianca Hoffmann; Carl-Magnus Svensson; Marc Thilo Figge; Ingrid Hilger; Florian H Heidel; Frank- D Böhmer; Jörg P Müller
Journal:  Oncogene       Date:  2019-02-28       Impact factor: 9.867

Review 8.  CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells.

Authors:  Michelle L Hermiston; Julie Zikherman; Jing W Zhu
Journal:  Immunol Rev       Date:  2009-03       Impact factor: 12.988

9.  N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death.

Authors:  Lesley A Earl; Shuguang Bi; Linda G Baum
Journal:  J Biol Chem       Date:  2009-11-17       Impact factor: 5.157

10.  Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.

Authors:  Rekha G Panchal; Ricky L Ulrich; Steven B Bradfute; Douglas Lane; Gordon Ruthel; Tara A Kenny; Patrick L Iversen; Arthur O Anderson; Rick Gussio; William C Raschke; Sina Bavari
Journal:  J Biol Chem       Date:  2009-03-06       Impact factor: 5.157
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